Hybrid Gold/Chiral Br?nsted Acid Relay Catalysis Allows an Enantioselective Synthesis of (-)-5-epi-Eupomatilone-6

摘要

An enantioselective synthesis of (-)-5-epi-eupomatilone-6 has been accomplished by using relay catalytic cascade intramolecular hydrosiloxylation and Mukaiyama aldol reaction of 2,3,4-trimethoxy-6-(phenylethynyl)phenyl dimethylsilanol with fluorenylglyoxylate.