Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment

摘要

The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading—release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.