Aerobic iron(III)-catalyzed direct formylation of imidazo[1,2-a] pyridine using DMSO as carbon source

摘要

A novel and efficient iron(III)-catalyzed C3-formylation reaction of imidazo[1,2-a]pyridine in an oxygen atmosphere has been developed. The method is conducted in dimethyl sulfoxide (DMSO), which serves as both the carbonyl carbon source and solvent, in the presence of acetic acid to directly generate structurally diverse 3-formylimidazo[1,2-a]pyridine derivatives in moderate to good yields. (C) 2016 Elsevier Ltd. All rights reserved.