Bafilomycin M, a new cytotoxic bafilomycin produced by a Streptomyces sp isolated from a marine sponge Theonella sp.

摘要

A new 16-membered diene macrolide, bafilomycin M (1) was produced from a streptomyces sp. GIC10-1, which was originally isolated from a marine sponge Theonella sp. The structure of 1 was established by spectroscopic methods and this compound was found to exhibit cytotoxicity toward K-562, HL-60, SUPT-1, LNCaP tumor cells with IC50 values 0.060, 0.011, 0.047 and 0.389 mu g/mL, respectively. (C) 2016 Elsevier Ltd. All rights reserved.