A practical synthesis of C14-C26 fragment of anticancer drug, eribulin mesylate

Lavanya Nadella; Kiranmai Nayani; Mainkar Prathama S.; Chandrasekhar Srivari

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A practical synthesis of C14-C26 fragment of anticancer drug, eribulin mesylate

机译：实用合成抗癌药物甲磺酸艾瑞布林的C14-C26片段

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High yielding synthesis of C14-C26 fragment of eribulin is achieved from commercially available R-(+)-citronellol and 1,4-butane diol utilizing the chirality of citronellol 'methyl' centre as C25, organocatalytic epoxidation to install C23 chirality and Sharpless asymmetric dihydroxylation to install chirality at C20 and C17. (c) 2015 Elsevier Ltd. All rights reserved.

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2015年第29期|共3页
作者
Lavanya Nadella; Kiranmai Nayani; Mainkar Prathama S.; Chandrasekhar Srivari;
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正文语种 eng
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Chemotherapeutic agent; Neurotoxic effects; Keck allylation; S(N)2 cyclization;

机译：化学治疗剂;神经毒性作用;Keck烯丙基化;S（N）2环化;

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1. A practical synthesis of C14-C26 fragment of anticancer drug, eribulin mesylate [J] . Lavanya Nadella, Kiranmai Nayani, Mainkar Prathama S., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2015,第29期

机译：实用合成抗癌药物甲磺酸艾瑞布林的C14-C26片段
2. Structural corroboration of two important building blocks of the anticancer drug eribulin mesylate through two-dimensional NMR and single-crystal X-ray diffraction studies [J] . Pullela Srinivas Venkata, Acharya Vinod, Reddy Nagarjuna, Acta crystallographica. Section C, Structural chemistry. . 2016,第1期

机译：通过二维NMR和单晶X射线衍射研究证实抗癌药物甲磺酸艾瑞布林的两个重要组成部分的结构确证
3. Structural corroboration of two important building blocks of the anticancer drug eribulin mesylate through two-dimensional NMR and single-crystal X-ray diffraction studies [J] . Pullela Srinivas Venkata, Acharya Vinod, Reddy Nagarjuna, Acta crystallographica. Section F, Structural biology communications . 2016,第1期

机译：通过二维NMR和单晶X射线衍射研究的抗癌药物二林蛋白的两个重要构建块的结构巧克力
4. A Theoretical and Scientific Evaluation of the Potential to Form Sulfonic Acid Esters in Mesylate Salt Drug Substances and Drug Products [C] . Alina Domin Turza, Christopher M. McGinley, Robert J. Baker, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：对甲磺酸盐药物物质和药品形成磺酸酯的潜力的理论和科学评价
5. Characterization of the Mechanism of Action of Eribulin and A Study of the Causes of Peripheral Neuropathy with Microtubule-Targeting Drugs [D] . Smith, Jennifer Anne 2011

机译：Eribulin作用机制的表征以及微管靶向药物对周围神经病变的原因的研究
6. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein [O] . Tomohiro Nabekura, Tatsuya Kawasaki, Misuzu Jimura, 2020

机译：靶向微管的抗癌药物eribulin诱导药物外流转运蛋白P-糖蛋白
7. Structural corroboration of two important building blocks of the anticancer drug eribulin mesylate through two-dimensional NMR and single-crystal X-ray diffraction studies [O] . Srinivas Venkata Pullela, Vinod Acharya, Nagarjuna Reddy, 2016

机译：通过二维NMR和单晶X射线衍射研究的抗癌药物二林蛋白的两个重要构建块的结构粗制

A practical synthesis of C14-C26 fragment of anticancer drug, eribulin mesylate

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