Copper-II mediated tandem reaction between aromatic ketones and 2-aminobenzenethiol for the synthesis of 2-aroylbenzothiazoles

摘要

A novel copper(II) mediated tandem reaction was developed for the synthesis of 2-aroylbenzothiazoles from readily available aryl-alkyl ketones in the presence of oxygen in ethanol. This method is mild, operationally simple, makes the use of inexpensive CuBr2 as mediator, and affords the corresponding 2-aroylbenzothiazoles in moderate to good yield. (C) 2016 Elsevier Ltd. All rights reserved.