Preparation of Nd/Na heterogeneous catalyst from bench-stable and inexpensive Nd salt for an anti-selective catalytic asymmetric nitroaldol reaction

摘要

A Nd/Na heterobimetallic complex prepared from an amide-based chiral ligand, Nd alkoxide, and NaHMDS is a highly efficient heterogeneous catalyst for an and-selective catalytic asymmetric nitroaldol reaction. Nd alkoxide is sensitive to moisture, expensive, and scarce, making it difficult to use the Nd/Na catalyst in large-scale applications. Herein we describe a new protocol that allows for catalyst preparation from bench-stable and inexpensive NdCl3 center dot 6H(2)O with comparable catalytic activity. (C) 2016 Elsevier Ltd. All rights reserved.