Heterogeneous bimetallic ZnFe2O4 nanopowder catalysed facile four component reaction for the synthesis of spiro[indoline-3,2 '-quinoline] derivatives from isatins in water medium

摘要

The bimetallic ZnFe2O4 nanopowder, a dual Lewis acid base combined catalyst is found to efficiently catalyse a four component reaction for the synthesis of functionalized tetrahydrospiro[indoline-3,2'-quinoline] derivatives from arylamines, dialkyl acetylenedicarboxylates, isatin derivatives and cyclohexane-1,3-diones in water medium at room temperature. Reduced reaction time, operational simplicity, elimination of hazardous solvent and more importantly, easy recoverability and reusability of the nanopowder make the present methodology economical, green and sustainable. (C) 2015 Elsevier Ltd. All rights reserved.