Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction

Biju Purakkattle; Bitar Rema; Lim Yeon-Hee; Wang Ying; Berlin Michael; Aslanian Robert; McCormick Kevin

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Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction

机译：利用闭环复分解反应合成新型抗炎甾体大环化合物

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摘要

A novel class of 13 and 16 membered steroidal macrocycles were synthesized by using ring closing metathesis reaction from the readily available anti-inflammatory steroids such as prednisolone, 6-methyl prednisolone, and 16-methyl prednisolone. (C) 2014 Elsevier Ltd. All rights reserved.

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry 》 |2015年第4期| 共3页
作者
Biju Purakkattle; Bitar Rema; Lim Yeon-Hee; Wang Ying; Berlin Michael; Aslanian Robert; McCormick Kevin;
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正文语种 eng
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Steroids; Macrocyclic lactones; Ring closing metathesis; Prednisolone; Grubb's catalyst;

机译：类固醇;大环内酯;环封闭复分解;泼尼松龙;Grubb催化剂;

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1. Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction [J] . Biju Purakkattle, Bitar Rema, Lim Yeon-Hee, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2015 ,第4期

机译：利用闭环复分解反应合成新型抗炎甾体大环化合物
2. Ring-closing metathesis of enynes tethered by an N-O bond: Synthesis of 1,2-oxaza polycycles by Diels-Alder reaction of the ring-closing metathesis products [J] . Yang YK., Tae J. Synlett . 2003 ,第13期

机译：通过N-O键束缚的炔烃的闭环复分解：闭环复分解产物的Diels-Alder反应合成1,2-氧杂氮杂多环
3. An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis [J] . Christopher Cordier, Daniel Morton, Stuart Leach, Organic & biomolecular chemistry . 2008 ,第10期

机译：一种有效的合成不对称硅酮的方法：用于封闭环的底物，包括大环封闭，易位
4. Ruthenium–Indenylidene Complexes Bearing Saturated N-Heterocyclic Carbenes: Synthesis and Application in Ring-Closing Metathesis Reactions [C] . Stijn Monsaert, Els De Canck, Renata Drozdzak, NATO Advanced Study Institute on Green Metathesis Chemistry: Great Challenges in Synthesis, Catalysis and Nanotechnology . 2010

机译：含饱和N-杂环的钌 - 茚基三苯基复合物：在闭环复分解反应中的合成和应用
5. High regioselective ring -opening /cross metathesis of norbornene derivatives and ring -opening /ring -closing metathesis and their applications towards total synthesis of rostratins and synthesis of acid sensing ion channel inhibitors [D] . Liu, Zhuqing 2007

机译：降冰片烯衍生物的高区域选择性开环/交叉易位和开环/闭环易位及其在角蛋白的全合成和酸敏感离子通道抑制剂的合成中的应用
6. Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction [O] . Stuart S. Rankin, John J. Caldwell, Nora B. Cronin, -1

机译：具有挑战性的闭合环复分解反应合成掺入核糖的中环支架
7. An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis† †Electronic supplementary information (ESI) available: Full experimental details and copies of NMR spectra for key compounds. See DOI: 10.1039/b804769n Click here for additional data file. [O] . Cordier, Christopher, Morton, Daniel, Leach, Stuart, 2008

机译：一种有效的合成不对称硅酮的方法：用于封闭环的底物，包括大环封闭，复分解† †可用的电子补充信息（ESI）：完整的实验详细信息和关键化合物的NMR光谱副本。参见DOI：10.1039 / b804769n 单击此处获取其他数据文件。

Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction

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