Synthesis of 4-arylcoumarins via palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamates with diaryliodonium salts

摘要

The palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamate ester derivatives by using diaryliodonium(III) salts has been developed. With this method, 4-arylcoumarins were easily prepared in good to excellent yields under base-free conditions. Additionally, this protocol provided an efficient alternative for the preparation of related 4-arylated coumarin compounds which are useful in the access to 5-lipoxygenase inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.