Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach

摘要

A facile and efficient synthetic approach under the catalyst system of Pd(OAc)(2)/KOAc/TBAB/DMF was developed allowing for rapid preparation of 2-arylation derivatives of the natural product tanshinone I. This approach was featured by palladium-catalyzed C-C coupling through direct C-sp2-H activation at the a-position of the furan ring of tanshinone I. Compared to the literature procedures, our protocol exhibited better atom-economy and much improved yields. (C) 2015 Elsevier Ltd. All rights reserved.