Diphosphate formation using cyanuric chloride or triisopropylbenzenesulfonyl chloride as the activating agents

摘要

By using cyanuric chloride or 2,4,6-triisopropylbenzenesulfonyl chloride (TIPSC1) as the condensing agent and magnesium bromide as the promoter, the phosphate cross-coupling reactions are effectively carried out to give lipid-saccharide and pyrrolidine-guanosine diphosphates. Under optimized conditions, the TIPSCl-facilitated cross-coupling reactions complete in a short reaction time (～5 h) without the complication of possible self-coupling reactions.