Practical cleavage of trifluoroacetamides with p-toluensulfonic acid

摘要

A practical and efficient cleavage of trifluoroacetamides with p-TsOH·H2O has been developed. The deprotected amines are isolated directly from the reaction mixture as tosylate salts. This method can be applied to both secondary and tertiary trifluoroacetamides in good isolated yields.