Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis

摘要

Synthesis of substituted 4-benzyloxypyridinium salts by the addition of Grignard reagents to pyridine N-oxides provides an efficient route for obtaining substituted 4-pyridones or 4-aminopyridinium salts.Six-membered nitrogen-containing heterocyclic compounds are known to be prominent in medicinal chemistry (e.g., pyridines,piperidines,and piperazines) and this has encouraged researchers to develop new and efficient synthetic protocols to such moieties.