In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

Raman Vysabhattar; Krishna N. Ganesh

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In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

机译：原位合成8-Br / NH2腺嘌呤肽核酸（PNA）寡聚体以及与DNA的互补研究

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A new, novel and efficient in situ synthesis of 8-aminoadeninyi PNA oligomers from corresponding 8-bro-moadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes.

机译：据报道从相应的8-溴-腺嘌呤基PNA低聚物中新颖，新颖和有效地原位合成8-氨基腺嘌呤PNA低聚物。对（8-Br / 8-NH2）PNA低聚物与cDNA的杂交特性的研究揭示了衍生的三链体和双链体的取代位点依赖性稳定作用。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2010年第50期|共5页
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Raman Vysabhattar; Krishna N. Ganesh;
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1. In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA [J] . Raman Vysabhattar, Krishna N. Ganesh Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第50期

机译：原位合成8-Br / NH2腺嘌呤肽核酸（PNA）寡聚体以及与DNA的互补研究
2. Backbone-extended pyrrolidine peptide nucleic acids (bepPNA): design, synthesis and DNA/RNA binding studies [J] . Govindaraju T, Kumar VA Chemical Communications . 2005,第4期

机译：骨干延伸的吡咯烷肽核酸（bepPNA）：设计，合成和DNA / RNA结合研究
3. Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils [J] . Chun-dong Liu, Jian-hua Wang, Yang Xie, MedChemComm . 2017,第2期

机译：含有5-卤素的肽核酸的合成和DNA / RNA互补研究
4. Molecular recognition of DNA sequences by peptide nucleic acids(PNAs)visualized by interaction with a cyanine dye [C] . Stefano Sforza, Tullia Tedeschi, Elena Cappelli International Peptide Symposium;European Peptide Symposium . 2005

机译：通过与青色染料相互作用可视化肽核酸（PNA）的DNA序列的分子识别
5. Synthetic studies on peptide nucleic acids: 1. Toward a circular bis-peptide nucleic acid. 2. Sequence and linker effects in bis-PNA hybridization to DNA. [D] . Tse, Joseph. 2004

机译：肽核酸的合成研究：1.形成环状双肽核酸。 2. bis-PNA与DNA杂交中的序列和接头效应。
6. Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils [O] . Chun-dong Liu, Jian-hua Wang, Yang Xie, 2017

机译：含5-氟尿嘧啶的肽核酸的合成及DNA / RNA互补研究
7. Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding. [O] . Yuliya Kirillova, Nataliya Boyarskaya, Andrey Dezhenkov, 2015

机译：聚阴离子羧乙基肽核酸（ce-pNas）：合成和DNa结合。
8. Cell Permeable Nanoconjugates of Shell-Crosslinked Knedel (SCK) and Peptide Nucleic Acids ('PNAs') with Uniquely Expressed or Over-Expressed mRNA Targeting Sequences for Early Diagnosis and Therapy of Cancer. [R] . Becker, M. L., Fang, H., Li, X., 2005

机译：具有独特表达或过度表达的mRNa靶向序列的壳交联克奈德（sCK）和肽核酸（'pNas'）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗。

In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

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