A new method for cleavage of silicon-carbon linkers on glass plate supports with applications to solid-phase syntheses on silica resins

摘要

We describe herein a novel and facile method for the cleavage of a silicon-based linker on solid-phase supports such as glass plates or silica resin. The linker was efficiently cleaved by oxidation of the silicon-carbon bond (Tamao-Kumada oxidation) to release the functionalized molecule.