Convergent synthesis of oligomers of triazole-linked DNA analogue (~(TL)DNA) in solution phase

Tomoko Fujino; Naomi Yamazaki; Hiroyuki Isobe

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Convergent synthesis of oligomers of triazole-linked DNA analogue (~(TL)DNA) in solution phase

机译：溶液相中三唑连接的DNA类似物（〜（TL）DNA）的低聚物的聚合合成

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摘要

A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA (~(TL)DNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer ~(TL)DNA in good yield.

机译：已开发出一种溶液相合成寡聚三唑连接的DNA（〜（TL）DNA）类似物的收敛途径。通过一锅法对被掩盖的乙炔进行甲硅烷基化反应以及随后的铜催化寡聚物之间的惠斯根偶联反应，可以使溶液中的7-mer和8-mer〜（TL）DNA合成得到良好的收率。

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来源
《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2009年第28期|共3页
作者
Tomoko Fujino; Naomi Yamazaki; Hiroyuki Isobe;
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原文格式 PDF
正文语种 eng
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关键词
Click chemistry; Artificial oligonucleotide; Convergent synthesis; Solution-phase synthesis;

机译：点击化学;人工寡核苷酸;收敛合成;溶液相合成;

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专利

1. Convergent synthesis of oligomers of triazole-linked DNA analogue (~(TL)DNA) in solution phase [J] . Tomoko Fujino, Naomi Yamazaki, Hiroyuki Isobe Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2009,第28期

机译：溶液相中三唑连接的DNA类似物（〜（TL）DNA）的低聚物的聚合合成
2. Efficient and improved synthesis of triazole-linked DNA (~(TL)DNA) oligomers [J] . Tomoko Fujino, Naomi Yamazaki, Ai Hasome Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2012,第7期

机译：高效和改进的三唑连接的DNA（〜（TL）DNA）低聚物的合成
3. Synthesis and structures of deoxyribonucleoside analogues for triazole-linked DNA (~(TL)DNA) [J] . Tomoko Fujino, Nobuhide Tsunaka, Marine Guillot-Nieckowski Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第15期

机译：三唑连接的DNA（〜（TL）DNA）的脱氧核糖核苷类似物的合成和结构
4. New methods for DNA oligomer-binding and detection in the DNA microarray technology [C] . Andras Gyorffy International IEEE Conference on Polymers and Adhesives in Microelectronics and Photonics . 2002

机译：DNA微阵列技术中DNA低聚物结合和检测的新方法
5. Self-aligned DNA oligomer and the deposition of DNA oligomers on EBL patterned cationic SAMS on Silicon dioxide/Silicon [100] [D] . Kim, Kyoung Nan 2012

机译：自对准DNA低聚物和DNA低聚物在二氧化硅/硅上的EBL图案化阳离子SAMS上的沉积[100]
6. DNA-Encoded Solid-Phase Synthesis: Encoding LanguageDesign and Complex Oligomer Library Synthesis [O] . AndrewB. MacConnell, Patrick J. McEnaney, ValerieJ. Cavett, -1

机译：DNA编码的固相合成：编码语言设计和复杂低聚物文库的合成
7. 1,4-linked 1,2,3-Triazole des-peptidic analogues of PNA (TzNA): Synthesis of TzNA oligomers by “click” reaction on solid phase and stabilization of derived triplexes with DNA [O] . Devi, Gitali, Ganesh, Krishna N 2010

机译：PNA（TzNA）的1,4-连接的1,2,3-三唑去肽类似物：通过固相“点击”反应合成稳定的TzNA低聚物，并用DNA稳定衍生的三链体

Convergent synthesis of oligomers of triazole-linked DNA analogue (~(TL)DNA) in solution phase

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