Efficient one-pot synthetic approaches for cannabinoid analogues and their application to biologically interesting (-)-hexahydrocannabinol and (+)-hexahydrocannabinol

摘要

This Letter reports new and efficient synthetic approaches for biologically interesting cannabinoid analogues.The key strategies involve ethylenediamine diacetate/triethylamine-catalyzed cyclization.As an application of this methodology,one-step synthesis of biologically active natural (-)-hexahydrocannabinol and its unnatural enantiomer (+)-hexahydrocannabinol was carried out.