Highly efficient three-component(aldehyde-alkyne-amine)coupling reactions catalyzed by a reusable PS-supported NHC-Ag(I)under solvent-free reaction conditions

摘要

The development of a highly efficient,polystyrene-supported NHC-Ag(I)catalyst for the three-component coupling reactions of aldehydes,alkynes,and amines(A~3-coupling)was described.In the presence of PS-NHC-Ag(1)(2 mol %),the A~3-reactions were carried out at room temperature under solvent-free reaction conditions and the corresponding propargylamines were generated in good to excellent yields.Furthermore,the catalyst could be reused at least 12 times without a significant loss of its catalytic activity.