Formal total synthesis of borrelidin: synthesis of C1-C11 fragment via desymmetrization strategy

摘要

A stereoselective formal total synthesis of borrelidin is described. The synthetic strategy for synthesis of C1-C11 fragment features desymmetrization of Diels-Alder adduct, Sharpiess asymmetric epoxidation, regioselective opening of chiral epoxide, and alkylation using Evans chiral auxiliary.