The fragmentation reaction of 16R-bromopregnane-3S,20S-diol

Jing-Rong Lin; Nan-Yan Zhou; Qi-Hai Xu

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The fragmentation reaction of 16R-bromopregnane-3S,20S-diol

机译：16R-溴孕烯-3S，20S-二醇的裂解反应

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16R-Bromopregnane-3S,20S-diol reacted with potassium t-butoxide to afford androst-16-en-3S-ol in a moderate yield viafragmentation reaction. The latter is a key intermediate for the synthesis of 5alpha-androst-16-en-3-one, as boar sex pheromone, andother steroidal drugs. In addition, 16R,20S-epoxypregnane-3S-ol was also obtained as a major product by changing the reactionsolvent.

机译：16R-溴代孕烷-3S，20S-二醇与叔丁醇钾反应，通过片段化反应以中等收率得到雄甾烯-16-en-3S-ol。后者是用于合成5alpha-androst-16-en-3-one（公猪性信息素）和其他甾体药物的关键中间体。另外，通过改变反应溶剂，也获得了16R，20S-环氧孕烷-3S-ol作为主要产物。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2007年第29期|共3页
作者
Jing-Rong Lin; Nan-Yan Zhou; Qi-Hai Xu;
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正文语种 eng
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关键词
Tigogenin; Pregnanetriol; 16R-Bromopregnane-3S; 20S-diol; Fragmentation.;

机译：Tigogenin;孕烯醇;16R-溴孕烯-3S;20S-二醇;断裂;

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1. The fragmentation reaction of 16R-bromopregnane-3S,20S-diol [J] . Jing-Rong Lin, Nan-Yan Zhou, Qi-Hai Xu Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2007,第29期

机译：16R-溴孕烯-3S，20S-二醇的裂解反应
2. Fragmentation reactions of protonated peptides containing phenylalanine: a linear free energy correlation in the fragmentation of H-Gly-Xxx-Phe-OH [J] . Alex G. Harrison International journal of mass spectrometry . 2002,第1a3期

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The fragmentation reaction of 16R-bromopregnane-3S,20S-diol

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