A one-pot synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from beta-keto esters and amidoximes under solvent-free conditions

摘要

Herein we report a high yielding one-pot 'green' synthesis of 3-substituted-5-carbonylmethyl-l,2,4-oxadiazoles from readily available beta-keto esters and amidoximes under simple and convenient solvent-free conditions.No additional base is needed.The reaction likely goes through an acyl ketene intermediate.