Synthesis and reactivity of 4 ''-phenylsulfinimine-avermectin B-1 and 4 '-phenylsulfinimine-avermectin B-1 monosaccharide derivative

摘要

A short, efficient synthesis of 4"-(R or S) 4"-deoxy-4"-amino4'-C substituted avermectin B-1 and 4'-(R or S)-4'-deoxy-4'amino-4'-C substituted avermectin B-1 monosaccharide 3 and 4 has been developed through the nucleophilic addition of an organometallic reagent to an intermediate phenylsulfinimide 7. These new derivatives of avermectin B-1 exhibited potent, broad spectrum insecticidal activity. (c) 2006 Elsevier Ltd. All rights reserved.