New syntheses for 11-(mercaptoundecyl)triethylene glycol and mercaptododecyltriethyleneoxy biotin amide

摘要

Novel syntheses for mercaptododecyltriethyleneoxy biotin amide and ll-(mercaptoundecyl)triethylene glycol are presented here.Such alkyl thiols are popular components in creating monolayers capable of specifically binding proteins.The development of a variety of functionalized alkyl thiol compounds has a great impact on biosensor substrate design.In our synthesis of mercaptododecyltriethyleneoxy biotin amide,we couple aminotriethyleneoxydodecane disulfide to the NHS-activated biotin;this technique is amenable to attaching a carboxylated molecule of interest in order to create the functionalized alkyl thiol of choice.The ll-(mercaptoundecyl)triethylene glycol synthesis presented here is an alternative method easily completed in three steps.