A practical synthesis of 2-(N-substituted)-amino-benzimidazoles utilizing CuCl-promoted intramolecular cyclization of N-(2-aminoaryl)thioureas

摘要

A practical protocol for synthesis of 2-(N-substituted)-aminobenzimidazoles was developed.N-(2-Aminoaryl)thioureas undergo a CuCl-promoted intramolecular cyclization to give the corresponding 2-(N-substituted amino)benzimidazoles in good to excellent isolated yields.