N-Alkylation of diethyl acetamidomalonate:synthesis of constrained amino acid derivatives by ring-closing metathesis

摘要

An efficient method for N-alkylation of diethyl acetamidomalonate(DEAM)is reported.C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs_2CO_3.RCM reactions of C-and N-alkenylated products gave cyclic amino acid derivatives in good yields.