A new strategy for synthesizing the steroids with side chains from steroidal sapogenins:synthesis of the aglyone of OSW-1 bu using the intact skeleton of diosgenin

摘要

The protected aglycone of saponin OSW-1,a new antitumor natural product,was synthesized in 13 linear steps in 9.5% overall yield by utilizing the intact skeleton of diosgenin.This strategy demonstrated a higher efficiency than the routine synthesis of steroids with side chains.