Synthesis of (4R~*,5R~*)-4-acetylamino-5-diethylcarbamoyl-cyclohex-1-ene -1-carboxylic acid and (3R~*,4R~*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid;new inhibitors of influenza virus sialidases

摘要

(4R~*,5R~*)-4-Acetylamino-5-diethylcarbamolylcyclohex-1-ene-1-carboxylic acid and (3R`*,4R~*)-4-acetylamino-3-diethyl-carbamoylcyclohex-1-ene-1-carboxylic acid have been synthesised using a Diels-Alder tactic;both compounds are selective inhibitors of influenza A sialidase,the latter compound being particularly potent.