Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

摘要

The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms in satisfactory yields. Two representative X-ray structures are reported. (C) 2015 Elsevier Ltd. All rights reserved.