Fluorinated NH-iminophosphonates and iminocarboxylates: novel synthons for the preparation of biorelevant α-aminophosphonates and carboxylates

摘要

A convenient synthetic approach to previously unknown NeH α-iminophosphonates and iminotrifluoropropionates was developed. The synthetic potential of NeH iminophosphonates and iminotrifluoropropionates, existing as an equilibrium mixture of E/Z-isomers, was demonstrated by their easy functionalization to afford biorelevant fluorinated α-aminophosphonic and α-aminocarboxylic acid derivatives.