Facile access to oxazolidin-2-imine, thiazolidin-2-imine and imidazolidin-2-imine derivatives bearing an exocyclic haloalkyliene via direct halocyclization between propargylamines, heterocumulenes and I-2 (NBS)

摘要

A simple, cheap, efficient, and metal-free method for one-step synthesis of a library of 1,3-diheteroatom five-membered heterocycles with exocyclic C=N and C=C double bonds was presented. The convenient reactions proceed via the direct three-component halocyclization of propargylamines, heterocumulenes and I-2 (NBS). (C) 2015 Elsevier Ltd. All rights reserved.