Pd(II)-catalyzed synthesis of indoles from α-aryloxime O-pentafluorobenzoates via intramolecular aromatic C-H amination

摘要

α-Aryl-a-aminocarbonyloxime O-pentafluorobenzoates are found to be promising precursors for synthesis of 2 3-disubstituted indole derivatives catalyzed by PdCl_2(MeCN)_2 in the presence of MgO as a base. The reaction is supposed to proceed via intramolecular aromatic C-H amination of a vinyl nitrene-palladium intermediate.