Synthetic transformations mediated by the combination of titanium(IV) alkoxides and grignard reagents: selectivity issues and recent applications. Part 1: reactions of carbonyl derivatives and nitriles

摘要

The present review deals with the chemistry of the organotitanium species formed by the reaction of titanium alkoxides of the form XTi(OR)3 (XMe, Cl, OR; Ralkyl) and excess amounts of Grignard reagents. This research area has emerged with the original discovery of a carboxylic ester cyclopropanation process, now commonly referred to as the Kulinkovich reaction, and first reported in 1989 by the group of Kulinkovich in Minsk, Belarus.