Synthesis of enantiomeric bridgehead substituted bisnoradamantane derivatives

摘要

The preparation of (+)- and (?)-12 by resolution of (±)-12 with (R)-N-phenylpantolactam, (R)-13, is described. From (+)- and (?)-12 a series of chiral bisnoradamantane derivatives, whose chirality stems from substitution at the bridgehead positions, have been obtained in both enantiomeric forms.