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首页> 外文期刊>Cornea >Healing Rate of Corneal Erosions: Comparison of the Effect of Chloramphenicol Eye Drops and Ointment and High-Concentration Hyaluronic Acid in an Animal Model
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Healing Rate of Corneal Erosions: Comparison of the Effect of Chloramphenicol Eye Drops and Ointment and High-Concentration Hyaluronic Acid in an Animal Model

机译:角膜侵蚀的治愈率:氯霉素滴眼液和软膏与高浓度透明质酸在动物模型中的作用比较

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摘要

Purpose: The aim of this study was to compare the effect of chloramphenicol eye drops or ointment, high-concentration hyaluronic acid, or no treatment on reepithelialization of corneal erosions in an experimental model.Methods: Uniform 6-mm corneal erosions were created in 23 rabbit eyes. The rabbits were randomized to 4 treatment groups: (1) chloramphenicol eye drops group, (2) chloramphenicol ointment, (3) hyaluronic acid 2.3%, and (4) untreated. Treatment was administered every 8 hours until reepithelialization occurred. Eyes were photographed every 8 hours with a cobalt blue-filtered light with fluores-cein drops until reepithelialization occurred. The area of the erosion at each time point was analyzed.Results: There were no significant differences in the reepithelialization of the corneal erosion among the 3 treatment groups (72-75 hours, P > 0.05). The time was significantly shorter (51 hours) for the control untreated group (P = 0.005).Conclusions: The use of chloramphenicol in the form of eye drops or ointment for prophylaxis in corneal erosions has a similar effect on the healing rate of the erosion. Both forms of the antibiotic and high-concentration hyaluronic acid had an effect of slowing down the healing of the erosion when compared with when no treatment was given. Therefore, the decision to treat erosions with eye drops or ointment can be based on the patient's comfort.
机译:目的:本研究的目的是在实验模型中比较氯霉素滴眼液或药膏,高浓度透明质酸或不治疗对角膜糜烂的再上皮形成的影响。方法:在23例中形成了均匀的6毫米角膜糜烂兔子的眼睛。将兔子随机分为4个治疗组:(1)氯霉素滴眼液组,(2)氯霉素软膏,(3)2.3%的透明质酸,和(4)未治疗。每8小时进行一次治疗,直到发生再上皮化。每隔8小时用钴蓝滤光片和荧光素滴眼对眼睛拍照,直到发生再上皮化。结果:3个治疗组之间角膜糜烂的再上皮形成没有显着差异(72-75小时,P> 0.05)。对照组的未处理时间明显缩短(51小时)(P = 0.005)。结论:以滴眼剂或软膏形式使用氯霉素预防角膜糜烂对糜烂的治愈率具有相似的作用。与不进行治疗时相比,两种形式的抗生素和高浓度的透明质酸均具有减缓糜烂愈合的作用。因此,决定使用眼药水或药膏治疗糜烂可以基于患者的舒适度。

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