Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz(191914–1978) on the occasion of the thirtieth anniversary of his death

摘要

The recognition of Se as an essential trace element and studies into its addition and value in animal feeds and foods are reviewed. Topics considered include: discovery of the element and its early history; approval of sodium selenite and sodium selenate as feed additives; problems with sodium selenite in feedstocks and supplements; selenomethionine, the chief nutritional form of Se; Se yeast as a source of food-form organic Se; fate of ingested selenomethionine; metabolism of selenite and selenate; the selenomethionine content of human tissues and organs; when Se deficiency is actually a selenomethionine deficiency; selenomethionine deficiency in TPN patients; local variations of the dietary Se supplies affecting animals and humans; Se for cancer-risk reduction; and critique of the current RDA for Se.