Biosynthesis of Resveratrol Dimers by Regioselective Oxidative Coupling Reaction

摘要

A wide array of natural resveratrol dimers was prepared by the regioselective oxidative coupling reaction of 3,5-di-(tertbutyl)resveratrol using several types of metal oxidants (Ag_2O, Ag_2CO_3, MnO_2, and FeCL_3-6F1_2O) in different solvent systems (benzene–acetone and dichloromethane). Subsequent debutylation of these coupling products resulted in racemic pallidol and ampelosin F.