A novel efficient four- and five-component, one-pot synthesis of 4-semicarbazonoalkyl-2-naphthols

摘要

One-pot, multicomponent coupling reaction of two or three molecules of aldehydes with 2-naphthols and semicarbazide hydrochloride is described for the preparation of 4-semicarbazonoalkyl-2-naphthols using PTSA/NaOAc as an efficient catalyst system in THF at room temperature or solvent-free conditions at elevated temperature.