Electrochemical carboxylation of alpha,alpha-difluorotoluene derivatives and its application to the synthesis of alpha-fluorinated nonsteroidal anti-inflammatory drugs

摘要

Electrochemical carboxylation of alpha,alpha-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding alpha-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of a-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs).