Aza-annulation of polarized N,S- and N,N-ketene acetals with itaconic anhydride: Synthesis of novel functionalized 1,2,3,4-tetrahydro-2-pyridones and related azabicycles

摘要

Synthesis of novel highly functionalized 2-oxo-(1,2,3,4-tetrahydropyridin-3-yl) acetic acids has been described via aza-annulation of both acyclic and cyclic alpha-oxo- and alpha-nitro-N,S-and-N,N-ketene acetals with itaconic anhydride.