COMBINING A CLICK-MULTICOMPONENT REACTION: ONE-POT SYNTHESIS OF 1,2,3-TRIAZOL-4-YLMETHYL 3-AMINO-5,10-DIHYDRO-5,10-DIOXO-1H-PYRAZOLO [1,2-b]PHTHALAZINE-2-CARBOXYLATE DERIVATIVES

摘要

(1,2,3-Triazol-4-yl)methyl-3-amino-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives were synthesized by a four-component, one-pot condensation reaction of benzaldehyde derivatives, an active methylene compound (prop-2-ynyl-2-cyanoacetate), azides, and phthalhydrazide in the presence of Cu(OAc)_2/sodium ascorbate as catalysts and 1-methyl-1H-imidazolium trifluoroacetate ([Hmim]TFA) as an ionic liquid medium in good to excellent yields.