COPPER(I) 3-METHYLSALICYLATE MEDIATES THE CHAN-LAM N-ARYLATION OF HETEROCYCLES

摘要

Copper(I) 3-methylsalicylate (CuMeSal) mediates N-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan-Lam coupling) under moderate reaction conditions (K2CO3, methanol, 65 degrees C, in air, 3-5h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of N-heterocycles were allowed to react and gave N-arylation products in reasonable yields, which demonstrate the utility of this catalyst.