Synthesis of novel p-tert-butylcalix[4]arene Schiff bases and their complexes with C-60, potential HIV-Protease inhibitors

摘要

Some p-tert-butylcalix[4]arene Schiff base crown ethers were synthesized, characterized using H-1, C-13-NMR, DEPT 135 and Mass spectrometry. Their complexes with C-60 were isolated and characterized. The inhibition effect of these complexes on HIVP was studied and found that complexes of 9 and 10 have comparable Ki values to Pepstatine which is known as HIVP inhibitor and used as a control. The synthesis of the ligands, complexes and the inhibition behavior are discussed in this article. (C) 2014 Elsevier B.V. All rights reserved.