Chelate-assisted oxidative coupling reaction of arylamides and unactivated alkenes: Mechanistic evidence for vinyl C-H bond activation promoted by an electrophilic ruthenium hydride catalyst

摘要

The cationic ruthenium hydride complex [(η~6-C _6H_6)(PCy_3)(CO)RuH]~+BF _4~- was found to be a highly regioselective catalyst for the oxidative C-H coupling reaction of aryl-substituted amides and unactivated alkenes to give o-alkenylamide products. The kinetic and spectroscopic analyses support a mechanism involving a rapid vinyl C-H activation followed by a rate-limiting C-C bond formation step.