Palladium Complexes of Planar Chiral Ferrocenyl Phosphine-NHC Ligands: New Catalysts for the Asymmetric Suzuki-Miyaura Reaction

摘要

Air-stable neutral and cationic palladium complexes bearing chiral phosphine-N-heterocyclic carbene ligands with planar chirality only have been prepared ill moderate to good yields and characterized by NMR and X-ray diffraction studies. They are shown to catalyze the asymmetric coupling of aryl bromides with arylboronic acids in good yields and moderate enantioselectivities (up to 42% ee) with low catalyst loadings (0.1-0.5 mol %).