A Three-Component Reaction for the Synthesis of 1-Azabicyclo[3.1.0]hexane-3-enes

摘要

A novel and simple synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives is described. The synthesis is carried out via a simple three-component reaction between aryl aldehydes, malononitrile, and hydroxylainine hydrochloride in water. Eco-friendliness excellent product yields) short reaction time, inexpensive and readily available starting materials, and interesting reaction and products are the main advantages of this method.