Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines

摘要

A general visible light induced photoredox-catalyzed radical trifluoromethylation/cyclization cascade of beta-aryl-beta,gamma-unsaturated hydrazones and mimes is described. The protocol enables an efficient access to various densely functionalized and biologically important CF3-containing dihydropyrazoles and isoxazolines with generally high yields.