Dehydrogenative Cross-Coupling Reaction by Cooperative Transition-Metal and Br?nsted Acid Catalysis for the Synthesis of β-Quinolinyl α-Amino Acid Esters

摘要

A novel dehydrogenative cross-coupling (DCC) reaction between methylquinoline derivatives and N-aryl glycine esters was developed by a cooperative catalysis of copper salt and Br?nsted acid, affording an efficient synthesis of β-quinolinyl α- amino acid esters. A plausible mechanism using a proton to activate the methylquinoline derivative and copper(II) to activate N-aryl glycine ester has been proposed.