Chiral phosphaalkene - Oxazoline ligands for the palladium-catalyzed asymmetric allylic alkylation

摘要

Enantioselective catalysis in moderate to excellent yields and ee's has been accomplished using a phosphaalkene-based ligand system. Specifically, the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate using a chiral P(sp~2),N(sp~2) ligand proceeds with a variety of malonate nucleophiles in 73 - 95% yield (79 - 92% ee).