Straightforward Synthesis of the Near-Infrared Fluorescent Voltage-Sensitive Dye RH1691 and Analogues Thereof

摘要

A highly straightforward synthesis of the near-infrared voltage-sensitive dye RH1691 is reported featuring two sequential anionic additions of C-nucleophilic heterocycles on a cyanine. This convergent approach led to the synthesis of four new probes, which also exhibit fluorescence in the near-infrared region.